Scientific paper 114 – New hVIVO authored paper published in PLOS One: “Accelerating Influenza Research: Vaccines, Antivirals, Immunomodulators and Monoclonal Antibodies. The Manufacture of a New Wild-Type H3N2 Virus for the Human Challenge Model”

January 14, 2016 2:22 pm

 

hVIVO, the pioneer of human disease models, is delighted to announce the publication of an hVIVO authored paper in PLOS (Public Library of Science), 13th January 2016.

Entitled “Accelerating Influenza Research: Vaccines, Antivirals, Immunomodulators and Monoclonal Antibodies. The Manufacture of a New Wild-Type H3N2 Virus for the Human Challenge Model” the paper’s lead author is Dr Dan Fullen, Lead Virologist at hVIVO Services Limited.

Influenza and its associated diseases are a major cause of morbidity and mortality. The United States Advisory Committee on Immunization Practices recommends influenza vaccination for everyone over 6 months of age, and the Centers for Disease Control and Prevention (CDC) recognises the H3N2 strain as being the most significant strain of influenza in the terms of morbidity and mortality. The failure of the flu vaccine in 2014-15 demonstrates the need for a model that allows the rapid development of novel antivirals, universal/intra-seasonal vaccines, immunomodulators, monoclonal antibodies and other novel treatments. To this end Dr Fullen and colleagues manufactured a new H3N2 influenza virus in compliance with Good Manufacturing Practice for use in the Human Viral Challenge Model, pioneered so successfully by hVIVO.

Dr Fullen commented : “Along with my fellow authors, we are delighted that this paper has been published. This pioneering work to manufacture a new H3N2 influenza virus for use in human challenge research models is important in the battle to overcome seasonal influenza and the significant impact it has on overall health so widely across the general population globally.”

The full authorship of the paper included: Dan Fullen, Nicolas Noulin, Andrew Catchpole, Hosnieh Fathi, Edward J. Murray, Alex Mann, Kingsley Eze, Ganesh Balaratnam, Daryl J. Borley, Anthony Gilbert and Rob Lambkin-Williams.

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