Scientific paper 115 – New hVIVO co-authored paper published in Oxford Journals “Open Forum Infectious Diseases” : “A genomic signature of influenza infection shows potential for presymptomatic detection, guiding early therapy, and monitoring clinical responses”

January 29, 2016 2:24 pm

hVIVO, the pioneer of human disease models, is delighted to announce the publication of an hVIVO co-authored paper in Oxford Journals “Open Forum Infectious Diseases”, 19 January 2016.

Entitled ““A genomic signature of influenza infection shows potential for presymptomatic detection, guiding early therapy, and monitoring clinical responses” the lead author is  Micah T. McClain, MD, PhD,  at Duke University Medical Center, Durham, North Carolina, USA.

The paper’s co-authors include Dr Rob Lambkin-Williams and Dr Anthony Gilbert from hVIVO Services Limited.

Abstract: Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in decreased overall influenza symptoms (aggregate symptom scores of 23.5 vs 46.3), more rapid resolution of clinical disease (20 hours earlier), reduced viral shedding (total TCID50 7.4 vs 9.7), and significantly reduced expression of several inflammatory cytokines (IFN-γ, TNF-α, IL-6 and others). The host genomic response to influenza infection is robust and may provide the means for early detection, more timely therapeutic interventions, a meaningful reduction in clinical disease and an effective molecular means to track response to therapy.

Dr Anthony Gilbert, hVIVO Medical Director, commented: ‘It has been a fantastic opportunity to collaborate on this study with the team from Duke University, one of the most prestigious universities in the U.S. This important research has great potential to assist in global efforts against influenza.’

Dr Rob Lambkin-Williams, hVIVO Executive Scientific Advisor, added: “Our program with Duke University has extended over many years. We are delighted to publish for the ninth time with data from the five clinical studies we have collaborated on, and there is even more exciting research to come.”

The full authorship of the paper is: Micah T. McClain, Bradly P. Nicholson, Larry P. Park, Tzu-Yu Liu, Alfred O. Hero III, Ephraim Tsalik,  Aimee K. Zaas, Timothy Veldman, Lori L. Hudson, Robert Lambkin-Williams, Anthony Gilbert, Geoffrey S. Ginsburg, and Christopher W. Woods.

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