Scientific Paper 106 – Effect of pre-existing serum and mucosal antibody on experimental respiratory syncytial virus (RSV) challenge and infection of adults

October 4, 2018 5:55 pm

Effect of pre-existing serum and mucosal antibody on experimental respiratory syncytial virus (RSV) challenge and infection of adults

Journal: Journal of Infectious Diseases, 2015;212(11):1719-1725

Authors: Bindiya Bagga, Jeffrey E. Cehelsky, Akshay Vaishnaw, Tom Wilkinson, Rachel Meyers, Lisa M. Harrison, Philippa L. Roddam, Edward E. Walsh and John P. DeVincenzo

Abstract

We studied pre-existing RSV-specific serum and nasal antibodies and their correlation with infectivity, viral dynamics and disease severity in a human experimental infection model. Higher pre-inoculation serum neutralizing antibody titers and nasal immunoglobulin (Ig) A predicted lower infectivity and lower measures of viral replication. However, once infected, no significant protective effect of pre-existing antibodies was seen. Lack of correlation between serum and mucosal antibodies was observed, implying that they are independent co-correlates of protection against RSV. We suggest that protection from RSV infection is a function of a complex interplay between mucosal and serum humoral immune responses.

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