Scientific Paper 106 – Effect of pre-existing serum and mucosal antibody on experimental respiratory syncytial virus (RSV) challenge and infection of adultsOctober 4, 2018 5:55 pm
Effect of pre-existing serum and mucosal antibody on experimental respiratory syncytial virus (RSV) challenge and infection of adults
Journal: Journal of Infectious Diseases, 2015;212(11):1719-1725
Authors: Bindiya Bagga, Jeffrey E. Cehelsky, Akshay Vaishnaw, Tom Wilkinson, Rachel Meyers, Lisa M. Harrison, Philippa L. Roddam, Edward E. Walsh and John P. DeVincenzo
We studied pre-existing RSV-specific serum and nasal antibodies and their correlation with infectivity, viral dynamics and disease severity in a human experimental infection model. Higher pre-inoculation serum neutralizing antibody titers and nasal immunoglobulin (Ig) A predicted lower infectivity and lower measures of viral replication. However, once infected, no significant protective effect of pre-existing antibodies was seen. Lack of correlation between serum and mucosal antibodies was observed, implying that they are independent co-correlates of protection against RSV. We suggest that protection from RSV infection is a function of a complex interplay between mucosal and serum humoral immune responses.