Scientific paper 47 – In vitro anti-HIV-1 virucidal activity of tyrosine-conjugated tri- and dihydroxy bile salt derivativesMarch 7, 2017 12:31 pm
In vitro anti-HIV-1 virucidal activity of tyrosine-conjugated tri- and dihydroxy bile salt derivatives
Journal of Antimicrobial Chemotherapy, (2000) 45 (5): 617-621
Authors: A A Al-Jabri, M D Wigg, E Elias, R Lambkin-Williams, C O Mills , J S Oxford
All the bile salt derivatives tested excluding DICGT were virucidal at a concentration as low as 10 ng/mL. DCT had the highest anti-HIV-1 virucidal potency, suggesting that monopeptide 7α,12α dihydroxy bile salt derivatives have the most potent antiviral activity. Complexing of iodine to the bile salt derivative (as in DICGT) decreases virucidal potency.