Open Orphan plc changed its name to hVIVO plc on 26 October 2022, learn more here.

Result Centre

Open Orphan plc has changed its name to hVIVO plc (Ticker: HVO)

Watch hVIVO’s Capital Markets Day 2022 presentation here.

Who Are We?

We are a rapidly growing specialist contract research organisation (CRO) and the world leader in testing infectious and respiratory disease vaccines and antivirals using human challenge clinical trials, providing end-to-end early clinical development services for its broad and longstanding client base of biopharma companies

Results Archive


Performance in 2022:

Yamin 'Mo' Khan


“I am pleased to report that the Group has leveraged the strong foundations laid in 2021, continuing its profitable momentum into 2022. Importantly, the Group achieved double digit EBITDA profit margins for the first time, a key goal for the business following the first full year of EBITDA profitability last year. In the second half, we expect revenues to grow considerably and profit margins to increase further as a number of significant contracts signed earlier in the year enter the clinic.

Going forward, I am highly encouraged by the Group's market-leading position, expanding addressable markets, and very substantial order book. With an order book of signed contracts worth c. £80m as at 1 September 2022, we have excellent forward visibility into H2 2022 and 2023, which gives us confidence in our ability to sustain our considerable organic growth over the long term. The Board expects to deliver full year revenues in line with guidance, and we look forward to the rest of 2022 and beyond with confidence.”

Latest Investor Presentation

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H1 2022 Revenue


H1 2022 EBITDA


H1 2022 Cash Balance


2022 Revenue Target


Our 4 Points for Investment

Strong market dynamics


Scalable infrastructure


Trusted Partner


Orderbook growth


Our values

At hVIVO, our values are more than just words. They are what define us.


One Team

We work as one high performing team, each playing to our best, committed to delivering shared goals with passion, energy and enthusiasm. Succeeding together is as important as succeeding individually. We celebrate that success together.



We are committed to growing and developing our employees, professionally and personally, through our unique experiences in a scientifically, intellectually, pioneering environment. Our vision is inspiring, opening up unexplored opportunities and the ability to achieve.



We take personal ownership for our actions and always act in ways that build trust and
respect with the people around us. We believe in clear, open and honest



We are pioneering in our approach, working with level headedness and listening to each other’s ideas. We are courageous in embracing new challenges and in our determination to do things differently and better. Our agility allows us to define and redefine our markets.

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