Scientific paper 2 – Influenza viruses induce autoantibodies to a brain-specific 37-kDa protein in rabbit

February 21, 2017 3:37 pm

Influenza viruses induce autoantibodies to a brain-specific 37-kDa protein in rabbit

Journal : PNAS (Proceedings of the National Academy of Sciences of the United States of America), March 1 1989, vol.86, no .6

Authors: P Laing, J G Knight, J M Hill, A G Harris, J S Oxford, R G Webster, M A Markwell, S M Paul, C B Pert


Immunization of rabbits with certain H1N1 influenza viruses, including the neurotropic strains NWS/33 and WSN/33 and the New Jersey/76 strain, resulted in the production of autoantibodies to a brain-specific protein of 37 kDa that is present in various species, including humans.

Autoantibodies were produced to brain only; various other tissues tested were negative. These antibodies were not elicited by other influenza A or B viruses, including closely related recombinant strains, but were elicited by the isolated hemagglutinin of A/Bellamy/42 strain and by formaldehyde-fixed WSN virus–demonstrating that infection was not essential for the induction of autoantibodies. In histological studies, reaction with anti-viral antisera was specific to gray matter and was confined to sera that recognized the 37-kDa protein. Antibody binding was prominent in regions comprised of neuronal cell bodies in cellular layers of the dentate gyrus, hippocampus, cerebral cortex, and cerebellum and was undetectable in myelin-rich regions, such as the corpus callosum. The 37-kDa protein, therefore, appears to be a neuronal antigen. Antibodies directed against this protein may be involved in the pathogenesis of one or more of the neuropsychiatric disorders that occur after infection with influenza.


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