Compound Efficacy & VRM

Supporting discovery and pre-clinical compound efficacy

Compound Efficacy Assessment Services

hLab offer compound efficacy assessment services to support Discovery and Pre-clinical compound efficacy for anti-viral compounds; post challenge or vaccination assessment of generation of genetic variants and shifts in compound efficacy.hLab offer compound efficacy assessment services to support Discovery and Pre-clinical compound efficacy for anti-viral compounds; post challenge or vaccination assessment of generation of genetic variants and shifts in compound efficacy.

Includes:

Effective concentration 50% (EC₅₀) (TCID₅₀ and plaque reduction) determination for candidate antivirals against Coronavirus alpha and beta (OC43, 229E, SARS-CoV2), RSV A & B and FLU (H3N2 & H1N1) viruses
Comparison to medically relevant antiviral compounds available commercially
Compound efficacy against hVIVO GMP challenge viruses and a wide range of other relevant related viruses to inform study design
Shifts in compound efficacy assessed by EC₅₀ and Next Generation Sequencing (NGS) for phenotypic and genotypic (variant analyses) antiviral resistance monitoring

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