Articles & Research
from hVIVO

RSV Vaccines/Prophylactics: Key learnings from the RSV challenge model and efficacy of vaccines

Challenge studies can be a powerful tool in the development of both therapeutic agents and vaccines. However, key decisions made in the study design process can have a profound impact...

Initial characteristics of respiratory viruses in symptomatic subjects during the pandemic, a cohort study

During the most intense waves of the recent pandemic, we have witnessed a clear and almost complete wipe-out of many respiratory viruses routinely circulating in the community over the north-hemisphere...

Immunomodulators and treatment of disease in the influenza human challenge model

Human challenge studies using wild-type viruses replicate what is seen in the field in the same populations, and as such they have been used to aid vaccine and drug development...

Human Challenge Studies: Their Conduct and Safety Aspects

If there would be a survey of 100 clinical research professionals either from CRO or from Pharma/Biotech industry to explain what a human challenge study is, the most common answer...

Scientific Paper

Treatment with the P2X3-Receptor Antagonist Gefapixant for Acute Cough in Induced Viral Upper Respiratory Tract Infection: A Phase 2a, Randomized, Placebo-Controlled Trial

RSV Human Challenge Study as a tool for a break-through designation

An international biotech company, headquartered in the EU approached hVIVO to explore the possibility of performing a RSV Phase IIa challenge study. The investigational product was a novel recombinant modified...

Infectious Diseases Blog – ‘The Pathogenda’ Part 5

In one of the most important discoveries in medicine this year, Epstein-Barr virus (EBV) has been collared as the link/early causal role in multiple sclerosis. Finding the virus underpinning multiple...

Infectious Diseases Blog – ‘The Pathogenda’ Part 4

So we know, or at least it is being widely reported, that depression and anxiety indices are raised worldwide, and most especially in High Income Countries (HIC). Whilst this is...

Scientific Paper

Human infection studies: Key considerations for challenge agent development and production

Infectious Diseases Blog – ‘The Pathogenda’ Part 3

Spring continues to bring its oft’ mixed blessings of sunshine and showers, as expressed over four hundred years ago in this short poem by Thomas Tusser in ‘A Hundred Good...