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Articles & Research
from hVIVO

Human Challenge Studies: Their Conduct and Safety Aspects

If there would be a survey of 100 clinical research professionals either from CRO or from Pharma/Biotech industry to explain what a human challenge study is, the most common answer...

Treatment with the P2X3-Receptor Antagonist Gefapixant for Acute Cough in Induced Viral Upper Respiratory Tract Infection: A Phase 2a, Randomized, Placebo-Controlled Trial

RSV Human Challenge Case Study

An international biotech company, headquartered in the EU approached hVIVO to explore the possibility of performing a RSV Phase IIa challenge study. The investigational product was a novel recombinant modified...

Infectious Diseases Blog – ‘The Pathogenda’ Part 5

In one of the most important discoveries in medicine this year, Epstein-Barr virus (EBV) has been collared as the link/early causal role in multiple sclerosis. Finding the virus underpinning multiple...

Infectious Diseases Blog – ‘The Pathogenda’ Part 4

So we know, or at least it is being widely reported, that depression and anxiety indices are raised worldwide, and most especially in High Income Countries (HIC). Whilst this is...

Scientific Paper

Human infection studies: Key considerations for challenge agent development and production

Infectious Diseases Blog – ‘The Pathogenda’ Part 3

Spring continues to bring its oft’ mixed blessings of sunshine and showers, as expressed over four hundred years ago in this short poem by Thomas Tusser in ‘A Hundred Good...

Infectious Diseases Blog – ‘The Pathogenda’ Part 2

Hello and welcome all to a sunny spring but one somewhat diminished in its capacity for ‘joy in the morning’ by a vicious uptick in BA.2 infections globally, with the...

Scientific Paper

Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults

Infectious Diseases Blog – ‘The Pathogenda’ Part 1