Articles & Research
from hVIVO

Unlock Your RSV Research: How hVIVO’s RSV Strains & Human Challenge Models can Revolutionise your RSV Research

Virus portfolio: Respiratory Syncytial Virus RSV was first discovered in 1956. It was initially identified in chimpanzees by Dr. Robert Chanock and his colleagues while working at the National Institutes...

Vaccine and drug efficacy in viral challenge models: Use of patient perception questionnaires

Human viral challenge studies are generally developed to quickly test efficacy of vaccines, prophylactics and treatments in a relatively small number of participants compared to Phase 2a/b field studies. hVIVO...

Use of Multiplex PCR for eligibility screening of human challenge study participants and for new virus Isolation

We detail the use of multiplex qualitative PCR for 2 specific reasons. Firstly, on admission to our Clinical site to test for the presence of a panel of respiratory pathogens...

The Human Viral Challenge Model with A/PERTH/16/2009 H3N2 a systematic analysis from five clinical studies

The human viral challenge model is well established, safe and ideal to study influenza. It allows researchers to illuminate each step of the infection: baseline, peak and return to healthy....

State-of-the-art facilities contribute substantially to human clinical trial efficacy outcomes

Respiratory pathogens, such as the Influenza virus and Respiratory Syncytial Virus (RSV), remain a significant disease burden globally causing high levels of acute respiratory infections, morbidity and mortality. Human challenge...

Newly developed influenza challenge agent panel based on recently circulating strains demonstrate high infectivity, symptomatology and febrile illness

Challenge models, also known as Controlled Human Infection Studies (CHIS), have emerged as invaluable tools for investigating host responses to respiratory virus infections and evaluating the efficacy of novel vaccines...

Bridging Airway Epithelial Cell Model and Human Challenge Studies

Airway epithelial cell differentiation in Air–Liquid Interface (ALI) condition closely mimics physiological environment of the human airway system, promoting enhanced oxygen availability and cellular differentiation. These conditions are valuable for...

Changes in memory and cognition during the SARS-CoV-2 human challenge study - ScienceDirect

Challenges in Respiratory Clinical Trials

Challenges in Clinical Research in Respiratory Diseases: Insights from the European Respiratory Society Congress Clinical research in respiratory diseases plays a pivotal role in advancing our understanding of various conditions,...

Tripledemic Takedown: How Human Challenge Trials are Ideal to Expedite Multivalent Vaccine Development

Introduction The recent rise of the "tripledemic" – the concurrent spread of the influenza virus, SARS-CoV-2 virus, and respiratory syncytial virus (RSV) – is posing significant risks, especially to older...